BIOGRAPHY

I am a Consultant Cardiologist and Electrophysiologist bridging clinical care between MKUH and OUH. I completed my training in the Oxford Deanery in 2021, and was lucky enough to complete a post-CCT EP Fellowship under Prof Kalyanan Shivkumar at UCLA, Los Angeles. There I was able to develop a wide breadth of EP and Devices with a keen focus on complex VT therapies. These included novel VT mapping techniques, hybrid surgical VT ablation and autonomic modulation therapy. I started my professional career as a Biochemist who migrated through Graduate-entry Medicine. These were sandwich by a PhD supervised by Prof David Lomas to dissect the cellular signalling process involved in protein misfolding in health and disease. This provided a strong foundation for my career as a Clinician Scientist. I have experience in molecular cell biology and in particular human stem cell derived cardiomyocytes and optogenetic control in patient with inherited channelopathy and cardiomyopathy. My clinical research interests are driven by mechanistic understanding of arrhythmia and how best to identify and risk stratify a personalised approach. I have started to work on machine learning technique to inform new workflows which can best serve a complex individual patient.

PUBLICATIONS

Lomas, D.A., Belorgey, D., Miranda, E., Mallya, M., Hägglof, P., Sharp, L.K., Phillips, R.L., Page, R., Davies, M.J. & Crowther, D.C. The Serpinopathies and Respiratory Disease, Chapter 20 (2006) Molecular and Cellular Aspects of the Serpinopathies and Disorders in Serpin Activity

Kennedy, S., van den Hurk, C., van Diepen, A., Coates, L.C., Miranda, E., Pérez, J., Davies, M.J., Lomas, D.A., Dunbar, R. & Birch, N.P. Expression of the serine protease inhibitor neuroserpin in cells of the human myeloid lineage, Thromb Haemost (2007) Mar; 97(3): 394-9

Miranda, E., McLeod, I., Davies, M.J., Pérez, J., Romisch, K., Crowther, D.C. & Lomas, D.A. The intracellular accumulation of polymeric neuroserpin explains the severity of the dementia FENIB, Hum Mol Genet (2008) Jun; 17(11): 1527-39

Davies, M.J. & Lomas, D.A. The molecular aetiology of the serpinopathies, Int J Biochem Cell Biol (2008) Jan; 40(6-7): 1273-86

Davies, M.J., Miranda, E., Marciniak, S.J., Roussell, B.D., Kaufman, R. & Lomas, D.A. Neuroserpin polymers activate NF-kB by a calcium signalling pathway that is independent of the unfolded protein response, J Bio Chem (2009) Jul; 284(27): 18202-9

Touma, O. & Davies, M.J. The prognostic value of end tidal carbon dioxide during cardiac arrest: a systematic review, Resuscitation (2013) Nov; 84(11): 1470-9

Davies, M.J., Harman, J., Yu, H., Bennett, M. & Jørgensen, H. The epigenetic phenotypic switch of vascular smooth muscle cells involved in atherosclerosis, Spring Meeting for Clinician Scientists in Training, Royal College of Medicine, London, Lancet (2013) Feb; 381(1): S34 Abstract

Harman, J., Madsen, R., Dalby, A., Davies, M.J., & Jørgensen, H. Epigenetic regulation of gene expression in vascular smooth muscle cells, Atherosclerosis (2015) 241(1): e79

Chang, Y.-F., Broyles, C. N., Brook, F. A., Davies, M. J., Turtle, C. W., Nagai, T., & Daniels, M. J. Non-invasive phenotyping and drug testing in single cardiomyocytes or beta-cells by calcium imaging and optogenetics, PLOS ONE (2017) 12(4): e0174181

Davies, M.J., & Newton, J. Non-invasive imaging in cardiology for the generalist, British J of Hosp Medicine (2017) 78(7): 392-398

Yasin, G., Davies, M.J., Firoozan, S., & Clifford, P. Safety, effectiveness and quality of nurse diagnostic coronary angiography, British Journal of Cardiology (2019) 26(2) 53-8

Davies, M.J., & De Palma, R. A compendium of international guidelines for interventional practice, The PCR-EAPCI Textbook Percutaneous Interventional Cardiovascular Medicine (2019)

Davies, M.J. & Rajappan, K. Defining the gap in epicardial pulmonary vein connectivity with high density mapping, J. Cardiovasc Electrophysiol (2021) 10.1111/jce.15176

Davies, M.J., Wijesurendra, R.S. & Betts, T.R. Detecting and managing atrial fibrillation in primary care. Practitioner (2021) 265(1852):17-20

El Diasty, M., Davies, M.J., Fernandez, A.L., Ribeiro, I., Payne, D., & Petsikas, D. Does pacemaker implantation after surgical aortic valve replacement impact long-term morbidity and mortality? A focused review. Tex Heart Inst J. (2022) 49(5):e207518

Robertson, C., Duffey, O., Tang, P-T., Fairhurst, N., Monteiro, C., Green, P., Grogono, J., Davies, M.J., Lewis, A., Wijesurendra, R., Ormerod, J., Gamble, J., Ginks, M., Rajappan, K., Bashir, Y., Betts, T. & Herring, N. An active fixation quadripolar left ventricular lead for cardiac resynchronisation therapy with reduced post-operative complications rates. J. Cardiovasc Electrophysiol (2022) Mar;33(3):458-463

Honarbakhsh, S., Martin, C.A., Dhillon, G., Gallagher, M., Sohal, M., Chow, A.W.C., Ahsan, S., Abbass, H., Whittaker-Axon, S., Lambiase, P.D., Davies, M.J., Ginks, M. & Hunter, R.J. High-Power Short Duration Ablation Results in High First-Pass Isolation: Effective Tool for Pulmonary Vein Isolation. SSRN (2022) 4199528

Tang, P.T., Davies, M.J., Bashir, Y., Betts, T.R., Pedersen, M., Rajappan, K., Ginks, M.R. & Wijesurendra, R.S. Efficacy and safety of same-day discharge after atrial fibrillation ablation compared with post-procedural overnight stay: a systematic review and meta-analysis. Europace (2022) 24, 1569-1584

Davies, M.J. & Bradfield, J.P. A virtual step towards precision scar-related ventricular tachycardia ablation. JACC CEP (2022) In press

Davies, M.J., Malik, V. & Moore, J.P. Ablation of free wall accessory pathways. Catheter Ablation of Cardiac Arrhythmias (2023) 4^th Edition, Chapter 21

Chung, W.H., Hayase, J., Davies, M.J., Do, D.H., Sorg, J.M., Ajijola, O.A., Buch, E.F., Boyle, N.G., Shivkumar. K., Bradfield J.S. Cryothermal energy demonstrates shorter ablation time and lower complication rates compared with radiofrequency in surgical hybrid ablation for recurrent ventricular tachycardia. Heart Rhythm. 2023 Sep 1:S1547-5271(23)02670-X

Davies, M.J., Kalla, M., Raine, D. Palin, C. & Bashir, Y. High Frequency Jet Ventilation and Catheter Ablation for Atrial Fibrillation: A Systematic Review and Meta-Analysis. Manuscript under submission