TCRG Editor 
Stress echocardiography is widely used to assess patients with chest pain. The clinical value of a positive or negative test result to inform on likely longer-term outcomes when applied in real-world practice across a healthcare system has not been previously reported. Click here to read the full paper.
In this paper we discuss the relevance of continuity equation based aortic valve area (AVA) calculation as a robust parameter suitable for accurate grading of aortic stenosis (AS) irrespective of flow conditions. Combining the AVA based grading and echocardiography-based staging, can provide with the most comprehensive clinical assessment of patients with AS and preserved left … Read more
TCRG Success story 2024 When a pure and simple research finding becomes a clinical reality – an example of a success of translational research from the Department of Cardiology MKUH. With great pride I am happy to share that our correction factor (CF), to improve transthoracic echocardiography derived LVOT area, therefore SV and AVA measurements … Read more
Please see a recent research letter on the subject of Perivascular inflammation and the coronarymicro-circulation and vasoreactivity — a potential clue to angina with non-obstructive coronary artery disease. The full letter can be read here.
Long-term outcome of contemporary stress echocardiography has not been systematically assessed. Please see the attached review that has the objective to evaluate the association between results of stress echocardiography and patients’ outcomes with suspected coronary artery disease using randomised controlled trials.
A 55-year-old woman with a 3-day history of abdominal pain and vomiting was admitted to our hospital. 7 days earlier she had a subtotal gastrectomy for poorly differentiated adenocarcinoma—stage T2N1M0. 24 h after admission, the patient was transferred to the cardiology ward for the management of chest pain associated with a raised high-sensitivity Troponin I … Read more
We are delighted to append the link/copy of this knowledge expanding and practice changing publication in The Lancet. We are a proud member of the ORFAN consortium and the writing committee. This work with the contribution of our local research group (TCRG-MKUH) Translational Cardiovascular Research Group – Milton Keynes University Hospital is a milestone of its kind. … Read more
Cardiac electrical biomarker (CEB), an indicator of ischaemia-induced change in myocyte polarity, has been proposed for diagnosis of acute coronary syndrome. However, effect of coronary occlusion on CEB has not been demonstrated. Click here to read the full article.
Continuous technologic development and updated recommendations for image acquisitions creates aneed to update the current normal reference ranges for echocardiography. The best method of indexing cardiac volumes is unknown. Click here to read the full article on the subject.
The latest achievement of our research group is the involvement in the National guidelines by British Echo Society on Contrast echocardiography. Ultrasound contrast agent (UCA) has been well established as a safe, cost-effective, and reliable imaging toolfor detecting heart disease. UCA is an essential component of echocardiography laboratories, it reduces the need for additional downstream … Read more