This study systematically evaluated the long-term outcomes of myocardial perfusion scintigraphy (MPS) in patients with suspected coronary artery disease (CAD). It analysed data from four trials involving 1764 patients with a median follow-up of 35.7 months. Positive MPS results, indicating reversible perfusion defects, were linked to higher risks of major adverse cardiovascular events (MACE) and all-cause or cardiovascular mortality. Annual event rates for positive MPS were 2.16% for MACE and 0.34% for mortality, compared to 0.66% and 0.10% for negative MPS results.
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